Continuous Lineage Decisions Uncovered by RNA Velocity
Project description
CellRank - Probabilistic Fate Mapping using RNA Velocity
CellRank is a toolkit to uncover cellular dynamics based on scRNA-seq data with RNA velocity annotation, see La Manno et al. (2018) and Bergen et al. (2019). CellRank models cellular dynamics as a Markov chain, where transition probabilities are computed based on RNA velocity and transcriptomic similarity, taking into account uncertainty in the velocities. The Markov chain is coarse grained into a set of metastable states which represent root & final states as well as transient intermediate states. For each cell, we obtain the probability of it belonging to each metastable state, i.e. we compute a fate map on the single cell level. We show an example of such a fate map in the figure above, which has been computed using the data of pancreatic endocrinogenesis.
CellRank scales to large cell numbers, is fully compatible with scanpy and scvelo and is easy to use. For installation instructions, documentation and tutorials, visit cellrank.org.
CellRank’s key applications
compute root & final as well as intermediate metastable states of your developmental/dynamical process
infer fate probabilities towards these states for each single cell
visualise gene expression trends towards/from specific states
identify potential driver genes for each state
Installation
Install CellRank by running:
pip install cellrank
Support
We welcome your feedback! Feel free to open an issue or send us an email if you encounter a bug, need our help or just want to make a comment/suggestion.
CellRank was developed in collaboration between the Theislab and the Peerlab.
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