Software platform for clinical neuroimaging studies
Project description
Clinica
Software platform for clinical neuroimaging studies
Homepage | Documentation | Forum | See also: AD-ML, AD-DL
About The Project
Clinica is a software platform for clinical research studies involving patients with neurological and psychiatric diseases and the acquisition of multimodal data (neuroimaging, clinical and cognitive evaluations, genetics...), most often with longitudinal follow-up.
Clinica is command-line driven and written in Python. It uses the Nipype system for pipelining and combines widely-used software packages for neuroimaging data analysis (ANTs, FreeSurfer, FSL, MRtrix, PETPVC, SPM), machine learning (Scikit-learn) and the BIDS standard for data organization.
Clinica provides tools to convert publicly available neuroimaging datasets into BIDS, namely:
- ADNI: Alzheimer’s Disease Neuroimaging Initiative
- AIBL: Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing
- NIFD: Neuroimaging in Frontotemporal Dementia
- OASIS: Open Access Series of Imaging Studies
Clinica can process any BIDS-compliant dataset with a set of complex processing pipelines involving different software packages for the analysis of neuroimaging data (T1-weighted MRI, diffusion MRI and PET data). It also provides integration between feature extraction and statistics, machine learning or deep learning.
Current pipelines are indicated in blue while new or updated pipelines are indicated in purple (will be released in Summer 2020).
Clinica is also showcased as a framework for the reproducible classification of Alzheimer's disease using machine learning and deep learning.
Getting Started
Full instructions for installation and additional information can be found in the user documentation.
Clinica currently supports macOS and Linux. It can be installed:
- With
conda(recommended):
conda create --name clinicaEnv python=3.6 clinica -c Aramislab -c conda-forge
- With
pip(needs Python 3.6)
pip install clinica
- Using the Developer installation
Depending on the pipeline that you want to use, you need to install pipeline-specific interfaces. Not all the dependencies are necessary to run Clinica. Please refer to this page to determine which third-party libraries you need to install.
Example
Diagram illustrating the Clinica pipelines involved when performing a group comparison of FDG PET data projected on the cortical surface between patients with Alzheimer's disease and healthy controls from the ADNI database:
- Clinical and neuroimaging data are downloaded from the ADNI website and data are converted into BIDS with the
adni-to-bidsconverter. - Estimation of the cortical and white surface is then produced by the
t1-freesurferpipeline. - FDG PET data can be projected on the subject’s cortical surface and normalized to the FsAverage template from FreeSurfer using the
pet-surfacepipeline. - TSV file with demographic information of the population studied is given to the
statistics-surfacepipeline to generate the results of the group comparison.
For more examples and details, please refer to the Documentation.
Support
- Report an issue on GitHub
- Use the Clinica Google Group to ask for help!
License
This software is distributed under the MIT License. See license file for more information.
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