VICC normalization routine for therapies
Project description
Therapy Normalization
Services and guidelines for normalizing drug (and non-drug therapy) terms
Developer instructions
The following sections include instructions specifically for developers.
Installation
For a development install, we recommend using Pipenv. See the pipenv docs for direction on installing pipenv in your compute environment.
Once installed, from the project root dir, just run:
pipenv sync
Deploying DynamoDB Locally
We use Amazon DynamoDB for our database. To deploy locally, follow these instructions.
Init coding style tests
Code style is managed by flake8 and checked prior to commit.
We use pre-commit to run conformance tests.
This ensures:
- Check code style
- Check for added large files
- Detect AWS Credentials
- Detect Private Key
Before first commit run:
pre-commit install
Running unit tests
Running unit tests is as easy as pytest.
pipenv run pytest
Updating the therapy normalization database
Before you use the CLI to update the database, run the following in a separate terminal to start DynamoDB on port 8000:
java -Djava.library.path=./DynamoDBLocal_lib -jar DynamoDBLocal.jar -sharedDb
To change the port, simply add -port value.
Setting Environment Variables
RxNorm requires a UMLS license, which you can register for one here.
You must set the RxNORM_API_KEY environment variable to your API key. This can be found in the UTS 'My Profile' area after singing in.
export RXNORM_API_KEY={rxnorm_api_key}
Update source(s)
The sources we currently use are: ChEMBL, NCIt, DrugBank, RxNorm, ChemIDplus, and Wikidata.
To update one source, simply set --normalizer to the source you wish to update.
From the project root, run the following to update the ChEMBL source:
python3 -m therapy.cli --normalizer="chembl"
To update multiple sources, you can use the normalizer flag with the source names separated by spaces.
Update all sources
To update all sources, use the --update_all flag.
From the project root, run the following to update all sources:
python3 -m therapy.cli --update_all
Create Merged Concept Groups
The normalize endpoint relies on merged concept groups.
To create merged concept groups, use the --update_merged flag with the --update_all flag.
python3 -m therapy.cli --update_all --update_merged
Specifying the database URL endpoint
The default URL endpoint is http://localhost:8000.
There are two different ways to specify the database URL endpoint.
The first way is to set the --db_url flag to the URL endpoint.
python3 -m therapy.cli --update_all --db_url="http://localhost:8001"
The second way is to set the THERAPY_NORM_DB_URL to the URL endpoint.
export THERAPY_NORM_DB_URL="http://localhost:8001"
python3 -m therapy.cli --update_all
Starting the therapy normalization service
From the project root, run the following:
uvicorn therapy.main:app --reload
Next, view the OpenAPI docs on your local machine:
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